Clinical Evidence

Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study.

Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T.

J Orthop Sci. 2014 Nov; 19 (6): 933-939.

The Oral Administration of Highly-Bioavailable Curcumin for One Year Has Clinical and Chondro-Protective Effects: A Randomized, Double-Blinded, Placebo-Controlled Prospective Study.

Nakagawa Y, Mori K, Yamada S, Mukai S, Hirose A, Nakamura R.

Arthrosc Sports Med Rehabil. 2022 Apr; 4 (2): 393-342. doi: 10.1016/j.asmr.2021.10.016

Short-term Effectiveness of Nexala® in the Treatment of Patients with Gonarthrosis and Coxarthrosis.

Pablo M, Nestor Z, Jorge L.

Jpn Pharmacol Ther 2021 49; (2): 229–238.

TC045

The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study.

Nakagawa Y, Mukai S, Yamada S, Murata S, Yabumoto H, Maeda T, Akamatsu S.

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 2020 13: 1–8.
doi: 10.1177/1179544120948471.

TC044

Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis.

Shin YA, Suk MH, Jang HS, Choi HJ.

J Exerc Rehabil. 2017 Dec; 13 (6): 684-692.

TC026

Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects.

Chung H, Yoon SH, Cho JY, Yeo HK, Shin D, Park JY.

International Journal of Clinical Pharmacology and Therapeutics. 2021 Oct; 59(10): 684-690.

Drinkable preparation of Theracurmin exhibits high absorption efficiency–a single-dose, double-blind, 4-way crossover study.

Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada T, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K.

Biol Pharm Bull. 2013; 36 (11): 1708-1714.

Innovative preparation of curcumin for improved oral bioavailability.

Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T.

Biol Pharm Bull. 2011; 34 (5): 660-665.

Theracurmin Supplementation May be a Therapeutic Option for Older Patients with Alzheimer’s Disease: A 6-Month Retrospective Follow-Up Study.

Dost FS, Kaya D, Ontan MS, Erken N, Bulut EA, Aydin AE, Isik AT.

Curr Alzheimer Res. 2021 Dec; 18 (14): 1087-1092. doi: 10.2174/1567205019666211221125255.

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.

Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J,Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR.  

Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277.

The Effect of Theracurmin on Cognitive Function in an Older Patient with Chemobrain.

Erken N, Dost Gunay FS, Soysal P, Isik AT.

Clin Interv Aging. 2020 May 19;15:691-693. doi: 10.2147/CIA.S252229. eCollection 2020.

The effects of curcumin on Brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study.

Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR.

Schizophrenia Res. 2018 May; 195: 572–573.

The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients.

Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR, Esdighiyan M, Djalali M, Honarvar NM, Djalali M.

Immunogenetics. 2017 Jun; 69 (6): 371-378.

A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.

Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.

Cancer Chemother Pharmacol. 2013 Jun; 71 (6): 1521-1530.

Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response.

Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK.

Front Oncol. 2013 May 29; 3: 137.

Theracurmin^® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest.

Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS.

Oncol Rep. 2016 Mar; 35 (3): 1463-1472. doi org/10.3892/or.2015.4537.

Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.

Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.

Nutr Res. 2012 Oct; 32 (10): 795-799.

Curcumin supplementation attenuates the decrease in endothelial function following eccentric exercise.

Choi Y, Tanabe Y, Akazawa N, Miyaki A, Maeda S.

J Exerc Nutrition Biochem. 2019 Jun 30; 23 (2):7-12. doi 10.20463/jenb.2019.0010.

Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study.

Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S.

Am J Hypertens. 2012 Jun; 25 (6): 651-656.

Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women.

Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.

Artery Res. 2013 Mar; 7 (1): 67-72.

Effects of a Health Drink Containing the Extract of the Hovenia Dulcis Fruit Stalk andTheracurmin, on Ethanol-Induced Hangover.

Kang NE, Oh YS, Yeo HK, Baik HW, Jang SE.

The Korean Society of Food culture. 2021; 36 (6): 1-8.

Effects of Theracurmin® consumption on liver function, fatigue, and sleep: a randomized, double-blind, placebo-controlled, parallel-comparison study.

Kuwabara Y, Hirose A, Lee HJ, Hashimoto D, Iio SI, and Takara T.

Functional Food in Health and Disease 2021 11; (6): 246-269.

Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.

Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K.

Eur J Appl Physiol. 2015 Sep; 115 (9): 1949-1957. doi 10.1007/s00421-015-3170-4

Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men.

Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H.

J Nutr Sci Vitaminol (Tokyo). 2019; 65 (1): 82-89. doi 10.3177/jnsv.65.82.

Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation.

Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H.

Scand J Med Sci Sports. 2019 Apr; 29 (4): 524-534. doi 10.1111/sms.13373.

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.

Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T.

Int J Chron Obstruct Pulmon Dis. 2016 Aug 26; 11: 2029-2034.

Clinical Application of “Curcumin”, a Multi-Functional Substance.

Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S.

Anti-Aging Medicine . 2012 Mar; 9(2): 75-83.

Novel Curcumin Oral Delivery Systems.

Kurita T, Makino Y.

Anticancer Res. 2013; 33 (7): 2807-2822.

Therapeutic applications of curcumin for patients with pancreatic cancer.

Kanai M.

World J Gastroenterol. 2014 Jul; 20 (28): 9384-9391.

Highly bioavailable curcumin (Theracurmin): its development and clinical application.

Imaizumi A.

PharmaNutrition. 2015 Oct; 3 (4): 123–130.

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.

Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T.

Cancer Chemother Pharmacol. 2012 Jan; 69 (1): 65-70.

Safety Evaluation of Theracurmin® in Healthy Japanese Adults. ―A Randomized, Double-blind, Placebo-controlled Parallel-group Study―

Takahashi T, Iio S, Takara T.

Jpn Pharmacol Thervol. 2019 Jul 1; 47(7): 1097-1113.