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List of Medical studies with Theracurmin®

        

 

Bioavailability
Absorption / Bioavailability TC025 Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J,Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR.
Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.
Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277.   (Fig.2)
Clinical
TC016 Sunagawa Y, Hirano S, Katanasaka Y, Miyazaki Y, Funamoto M, Okamura N, Hojo Y, Suzuki H, Doi O, Yokoji T, Morimoto E, Takashi T, Ozawa H, Imaizumi A, Ueno M, Kakeya H, Shimatsu A, Wada H, Hasegawa K, Morimoto T.
Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study.
J Nutr Sci Vitaminol (Tokyo). 2015; 61 (1): 37-44.
Clinical
TC011 Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada T, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K.
Drinkable preparation of Theracurmin exhibits high absorption efficiency–a single-dose, double-blind, 4-way crossover study.
Biol Pharm Bull. 2013; 36 (11): 1708-1714.
Clinical
TC001 Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T.
Innovative preparation of curcumin for improved oral bioavailability.
Biol Pharm Bull. 2011; 34 (5): 660-665.
Pre- clinical
&Clinical

 

 

Brain
Cognitive Function TC025 Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR.
Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.
Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277.
Clinical
Schizophrenia TC028 Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR.
The effects of curcumin on Brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study.
Schizophrenia Res. 2018 May; 195: 572–573.
Clinical
Migraine TC024 Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR, Esdighiyan M, Djalali M, Honarvar NM, Djalali M.
The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients.
Immunogenetics. 2017 Jun; 69 (6): 371-378.
Clinical

Cancer
Esophageal Adenocarcinoma TC008 Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK.
Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response.
Front Oncol. 2013 May 29; 3: 137.
in vitro
Prostate and Bladder Cancer TC021 Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS.
Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest.
Oncol Rep. 2016 Mar; 35 (3): 1463-1472. doi org/10.3892/or.2015.4537.
in vitro
Pancreas Cancer / Biliary Tract Cancer TC006 Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.
A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients. Cancer Chemother Pharmacol. 2013 Jun; 71 (6): 1521-1530.
Clinical

Oxidative stress/ Inflammatory
Exercise-Induced Oxidative Stress TC014 Takahashi M, Suzuki K, Kim HK, Otsuka Y, Imaizumi A, Miyashita M, Sakamoto S.
Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans.
Int J Sports Med. 2014 Jun; 35 (6): 469-475.
Clinical

Muscle
Effective timing of theracurmin to prevent muscle damage TC031 Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H.
Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men.
J Nutr Sci Vitaminol (Tokyo). 2019; 65 (1): 82-89. doi 10.3177/jnsv.65.82.
Clinical
TC029 Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H.
Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation.
Scand J Med Sci Sports. 2019 Apr; 29 (4): 524-534. doi 10.1111/sms.13373.
Clinical
Muscle recovery TC017 Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K.
Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.
Eur J Appl Physiol. 2015 Sep; 115 (9): 1949-1957. doi 10.1007/s00421-015-3170-4.
Clinical

      

Cardiovascular system
Endothelial Function TC034 Choi Y, Tanabe Y, Akazawa N, Miyaki A, Maeda S.
Curcumin supplementation attenuates the decrease in endothelial function following eccentric exercise.
J Exerc Nutrition Biochem. 2019 Jun 30; 23 (2):7-12.
doi 10.20463/jenb.2019.0010.
Clinical
Arteriosclerosis TC007 Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.
Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women.
Artery Res. 2013 Mar; 7 (1): 67-72.
Clinical
Vascular Endothelial Function TC005 Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.
Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
Nutr Res. 2012 Oct; 32 (10): 795-799.
Clinical
Central Arterial Hemodynamics TC004 Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S.
Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study.
Am J Hypertens. 2012 Jun; 25 (6): 651-656.
Clinical

Respiratory System
COPD (Chronic Obstructive Pulmonary Disease) TC018 Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T.
Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.
Int J Chron Obstruct Pulmon Dis. 2016 Aug 26; 11: 2029-2034.
Clinical

Arthritis
Knee Osteoarthritis TC026 Shin YA, Suk MH, Jang HS, Choi HJ.
Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis.
J Exerc Rehabil. 2017 Dec; 13 (6): 684-692.
Clinical
TC015 Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T.
Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study.
J Orthop Sci. 2014 Nov; 19 (6): 933-939.
Clinical

Tolerability
Safety data TC035 Takahashi T, Iio S, Takara T.
Safety Evaluation of TheracurminTM in Healthy Japanese Adults. ―A Randomized, Double—blind, Placebo—controlled Parallel—group Study―

Jpn Pharmacol Thervol. 2019 Jul 1; 47(7): 1097-1113.
Clinical
Safety and tolerability TC002 Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T.
Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.
Cancer Chemother Pharmacol. 2012 Jan; 69 (1): 65-70.
Clinical

Review
Theracurmin® TCR004 Imaizumi A.
Highly bioavailable curcumin (Theracurmin): its development and clinical application.
PharmaNutrition. 2015 Oct; 3 (4): 123–130.
Clinical
TCR003 Kurita T, Makino Y.
Novel Curcumin Oral Delivery Systems.
Anticancer Res. 2013; 33 (7): 2807-2822.
Clinical
TCR001 Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S.
Clinical Application of “Curcumin”, a Multi-Functional Substance.
Anti-Aging Medicine . 2012 Mar; 9(2): 75-83.
Clinical
Pancreas Cancer TCR002 Kanai M.
Therapeutic applications of curcumin for patients with pancreatic cancer.
World J Gastroenterol. 2014 Jul; 20 (28): 9384-9391.
Clinical