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News list

2021.06.18
【New treatise information】
2021.01.08
【Notification of Employees Working from Home】
In view of the effects of the spread of the new coronavirus, all employees will carry out targeted work from home during the period from January 12 until further notice in order to ensure the safety of employees and everyone involved in the Company.

For business partners, please contact us via e-mail or mobile phone or inquiry form in our website. We apologize for the inconvenience, and we ask for your understanding and continuous cooperation.
2020.12.25
【Notice of Office Closure】
Our office will be closed for the New Year’s holiday from December 29th(Tue) through January 3rd(Sun).
We will resume our business on January 4th(Mon).
2020.8.25
【Notification of Employees Working from Home】
In view of the effects of the spread of the new coronavirus, all employees will carry out targeted work from home during the period from August 26 to September 4 2020 in order to ensure the safety of employees and everyone involved in the Company. For business partners, please contact us by e-mail or mobile phone when making an order. We apologize for the inconvenience, and we ask for your continued understanding and cooperation.
2020.07.28
【Notice of Office Closure】
Our office will be closed for the summer holiday from Aug 13th(Thu) through Aug 16th(Sun).
We will resume our business on Aug 17th(Mon).
2019.12.13
【Notice of Office Closure】
Our office will be closed for the New Year’s holiday from December 28th(Sat) through January 5th(Sun).
We will resume our business on January 6th(Mon).

List of articles

THERACURMIN®

Bioavailability
Absorption / Bioavailability
TC025
Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J,Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277.  (Fig.2)
Clinical
TC016
Sunagawa Y, Hirano S, Katanasaka Y, Miyazaki Y, Funamoto M, Okamura N, Hojo Y, Suzuki H, Doi O, Yokoji T, Morimoto E, Takashi T, Ozawa H, Imaizumi A, Ueno M, Kakeya H, Shimatsu A, Wada H, Hasegawa K, Morimoto T. Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study. J Nutr Sci Vitaminol (Tokyo). 2015; 61 (1): 37-44.
Clinical
TC011
Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada T, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K. Drinkable preparation of Theracurmin exhibits high absorption efficiency–a single-dose, double-blind, 4-way crossover study. Biol Pharm Bull. 2013; 36 (11): 1708-1714.
Clinical
TC001
Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011; 34 (5): 660-665.
Pre- clinical &Clinical
Brain
Cognitive function
TC043
Erken N, Dost Gunay FS, Soysal P, Isik AT. The Effect of Theracurmin on Cognitive Function in an Older Patient with Chemobrain. Clin Interv Aging. 2020 May 19;15:691-693. doi: 10.2147/CIA.S252229. eCollection 2020.
Clinical
Cognitive function
TC025
Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277.
Clinical
Schizophrenia
TC028
Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR. The effects of curcumin on Brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study. Schizophrenia Res. 2018 May; 195: 572–573.
Clinical
Migraine
TC024
Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR, Esdighiyan M, Djalali M, Honarvar NM, Djalali M. The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics. 2017 Jun; 69 (6): 371-378.
Clinical
Liver
Liver function (ALT)
TC046
Kuwabara Y, Hirose A, Lee HJ, Hashimoto D, Iio SI, and Takara T. Effects of Theracurmin® consumption on liver function, fatigue, and sleep: a randomized, double-blind, placebo-controlled, parallel-comparison study. Functional Food in Health and Disease 2021 11; (6): 246-269.
Clinical
Cancer
Esophageal adenocarcinoma
TC008
Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK. Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response. Front Oncol. 2013 May 29; 3: 137.
in vitro
Prostate and bladder cancer
TC021
Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS. Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest. Oncol Rep. 2016 Mar; 35 (3): 1463-1472. doi org/10.3892/or.2015.4537.
in vitro
Pancreas cancer / Biliary tract cancer
TC006
Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H. A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients. Cancer Chemother Pharmacol. 2013 Jun; 71 (6): 1521-1530.
Clinical
Oxidative stress/ Inflammatory
Crohn’s disease
TC042
Sugimoto K, Ikeya K, Bamba S, Andoh A, Yamasaki H, Mitsuyama K, Nasuno M, Tanaka H, Matsuura A, Kato M, Ishida N, Tamura S, Takano R, Tani S, Osawa S, Nishihira J, Hanai H. Chemopreventive effects of nanopartic Highly Bioavailable Curcumin Derivative Ameliorates Crohn’s Disease Symptoms: A Randomized, Double-Blind, Multicenter Study. J Crohns Colitis.2020 May 15. doi: 10.1093/ecco-jcc/jjaa097. Online ahead of print.
Clinical
Exercise- induced oxidative stress
TC014
Takahashi M, Suzuki K, Kim HK, Otsuka Y, Imaizumi A, Miyashita M, Sakamoto S. Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans. Int J Sports Med. 2014 Jun; 35 (6): 469-475.
Clinical
Muscle
Effective timing of THERACURMIN® to prevent muscle damage
TC031
Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H. Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men. J Nutr Sci Vitaminol (Tokyo). 2019; 65 (1): 82-89. doi 10.3177/jnsv.65.82.
Clinical
TC029
Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports. 2019 Apr; 29 (4): 524-534. doi 10.1111/sms.13373.
Clinical
Muscle recovery
TC017
Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K. Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.
Eur J Appl Physiol. 2015 Sep; 115 (9): 1949-1957. doi 10.1007/s00421-015-3170-4
Clinical
Cardiovascular system
Endothelial function
TC034
Choi Y, Tanabe Y, Akazawa N, Miyaki A, Maeda S. Curcumin supplementation attenuates the decrease in endothelial function following eccentric exercise. J Exerc Nutrition Biochem. 2019 Jun 30; 23 (2):7-12. doi 10.20463/jenb.2019.0010.
Clinical
Arteriosclerosis
TC007
Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women. Artery Res. 2013 Mar; 7 (1): 67-72.
Clinical
Vascular endothelial function
TC005
Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct; 32 (10): 795-799.
Clinical
Central arterial hemodynamics
TC004
Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. Am J Hypertens. 2012 Jun; 25 (6): 651-656.
Clinical
Respiratory System
COPD (Chronic obstructive pulmonary disease)
TC018
Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T. Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD. Int J Chron Obstruct Pulmon Dis. 2016 Aug 26; 11: 2029-2034.
Clinical
Arthritis
Knee osteoarthritis
TC045
Pablo M, Nestor Z, Jorge L. Short-term Effectiveness of Nexala® in the Treatment of Patients with Gonarthrosis and Coxarthrosis.
Jpn Pharmacol Ther 2021 49; (2): 229–238.
Clinical
TC044
Nakagawa Y, Mukai S, Yamada S, Murata S, Yabumoto H, Maeda T, Akamatsu S. The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 2020 13: 1–8.
doi: 10.1177/1179544120948471.
Clinical
TC026
Shin YA, Suk MH, Jang HS, Choi HJ. Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. J Exerc Rehabil. 2017 Dec; 13 (6): 684-692.
Clinical
TC015
Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov; 19 (6): 933-939.
Clinical
Tolerability
Safety data
TC035
Takahashi T, Iio S, Takara T. Safety Evaluation of TheracurminTM in Healthy Japanese Adults. ―A Randomized, Double—blind, Placebo—controlled Parallel—group Study― Jpn Pharmacol Thervol. 2019 Jul 1; 47(7): 1097-1113.
Clinical
Safety and tolerability
TC002
Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol. 2012 Jan; 69 (1): 65-70.
Clinical
Review
THERACURMIN®
TCR004
Imaizumi A.
Highly bioavailable curcumin (Theracurmin): its development and clinical application.
PharmaNutrition. 2015 Oct; 3 (4): 123–130.
Clinical
TCR003
Kurita T, Makino Y.
Novel Curcumin Oral Delivery Systems.
Anticancer Res. 2013; 33 (7): 2807-2822.
Clinical
TCR001
Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S.
Clinical Application of “Curcumin”, a Multi-Functional Substance.
Anti-Aging Medicine . 2012 Mar; 9(2): 75-83.
Clinical
Pancreas cancer
TCR002
Kanai M.
Therapeutic applications of curcumin for patients with pancreatic cancer. World J Gastroenterol. 2014 Jul; 20 (28): 9384-9391.
Clinical

Information presented at academic conferences

2010
『2010 IFT Annual Meeting & Food Expo and Process Expo,』 Scientific Program 064-07 Imaizumi A. “Innovative curcumin preparation with improved oral bioavailability.”
『International Society for Nutraceuticals & Functional Foods』 Imaizumi A. “Innovative curcumin preparation with improved oral bioavailability.”
2011
『American Heart Association Scientific Sessions2011』 Morimoto T. “Effects of Highly Absorptive Curcumin on Systolic and Diastolic Function in Hypertensive Patients with Left Ventricular Hypertrophy.”
『The American College of Cardiology 61st Annual Scientific Session』 Morimoto T. “Highly Absorptive Curcumin Improves Left Ventricular Diastolic Function Regardless of Blood Pressure in Hypertensive Patients.”
『10th Symposium of the International Society of Exercise and Immunology』 Poster-72 Kawanishi N. “Curcumin attenuates oxidative stress via suppression of MCP-1 production following.” Young Investigator Award(best poster)
『2011 International Conference and Exhibition on Nutraceutical and Functional Foods (International Society for Nutraceuticals and Functional foods),』 Session 28 “Curcumin: Present and Future” Makino Y. “Oral absorption enhancement by novel nano-suspension technology: application to insoluble functional food materials.” Imaizumi A . “Potential health benefit of THERACURMIN (nano-particle curcumin): mechanism oriented human studies.” Kanai M. “Effect of curcumin for gemcitabine-resistant pancreatic cancer: A Phase I / II study of gemcitabine-based chemotherapy plus Theracurmin (nano-particle curcumin)” Ide H. “Prostate cancer and curcumin: current application and future prospect.” Hasegawa K. “Highly absorptive curcumin improves diastolic function in hypertensive patients with left ventricular hypertrophy.”
2012
『Japan-France DDS Symposium』 Makino Y. “Novel Curcumin Submicron (nano) -Suspensions with Enhanced Oral Bioavailability and Stability.”
『American Heart Association』 Scientific Sessions Morimoto T. “Effects of Highly Absorptive Curcumin on Systolic and Diastolic Function in Hypertensive Patients with Left Ventricular Hypertrophy.”
『American College of Cardiology』 Morimoto T. “Highly Absorptive Curcumin Improves Left Ventricular Diastolic Function Regardless of Blood Pressure in Hypertensive Patients.” J. Am. Coll. Cardiol. 2012; 59; E987
『2012 Annual Conference & Exhibition: Functional Foods, Nutraceuticals, Natural Health Products and Dietary Supplements (International Society for Nutraceuticals and Functional Foods)』 Imaizumi A. “Health Benefit of Highly Bioavailable Curcumin (Theracurmin®): Its Clinical Potential in Common Diseases Involving Chronic Inflammation.”
2013
『2013Cold Spring Harbor Conferences Asia, Tumor Immunology & Immunotherapy』 Hayakawa T. “Administration of a highly absorptive form of curcumin augments anti-tumor immune responses through reversal of cancer-induced immunosuppression via NF-kB and STAT3 inhibition.”
『International Sports Science Congress』 Maeda S. “Effect of curcumin on vascular endothelial function after high-intensity resistance.”
『2013 Gastrointestinal Cancers Symposium』 Kanai M. “A Phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin in cancer patients.”
『The 8th International Sport Sciences Symposium on “Active Life”』 Takahashi M. “Effects of curcumin supplementation on exercise-induced oxidative stress in humans.”
『2013 International Meeting of Asia Forum for Aesthetic Surgery & Medicine The 1st Congress of Asia Anti-Aging & Regenerative Medicine Korea Academy of Aesthetic Surgery & Medicine,』 Anti-aging session by World Academy of Anti-Aging & Regenerative Medicine Imaizumi A. “Highly bioavailable curcumin (Theracurmin®): its clinical potential in common diseases and anti-aging.”
2014
『The 29th Society for Immunotherapy of Cancer Annual Meeting』 Hayakawa T. “Enhanced anti-tumor effects of the PD-1/PD-L1 blockade by combining a highly absorptive form of NF-kB/STAT3 inhibitor curcumin.”
2017
『International Sports and Exercise Nutrition Conference』 Tanabe Y. “Curcumin Intake After Eccentric Exercise Effectively Reduces Muscle Damage and Enables Faster Recovery.”
『International Sport Exercise Nutrition Conference』 Poster Tanabe Y. “Curcumin intake after eccentric exercise effectively reduces muscle damage and enables faster recovery.”
2018
『256th ACS National Meeting(Boston, USA)』 Tsuda T. “Curcumin as a functional food-derived factor: Highly dispersible and bioavailable curcumin but not native curcumin effectively induces brown-like adipocyte formation in mice.”
2019

Information on exhibitions

March 2012
Exhibits at 2012 Natural Products Expo West
June 2014
Exhibits at iM 2014 (Ingredient Marketplace)
October 2014
Exhibits at SupplySide West 2014
December 2014
Exhibits at Hi Europe & Ni 2014
May 2015
Exhibits at Vitafoods Europe 2015
October 2015
Exhibits at SupplySide West 2015
March 2016
Exhibits at 2016 Natural Products Expo West
May 2017
Exhibits at Vitafoods Europe 2017
September 2017
Exhibits at SupplySide West 2017
November 2018
Exhibits at SupplySide West 2018
October 2019
Exhibits at SupplySide West 2019
June 2021
Exhibits at SupplySide East 2021 (planned)
October 2021
Exhibits at Vitafoods Europe 2021 (planned)