Theracurmin® Research & Clinical Trials


Anti-inflammatory Benefits of Curcumin

The importance of curcumin as an anti-inflammatory agent and its potential for beneficial, healing effects is the driving force behind curcumin research. Additionally curcumin has been shown to exhibit antioxidant, antiviral, antibacterial, antifungal, and anti-cancer properties. At Theravalues, we believe our Theracurmin® Highly Bioavailable Curcumin product has the potential to act as a protectant against many of today’s diseases.


Diseases Caused by Chronic Inflammation

The human body can harbor chronic inflammation that is detrimental to health. Inflammation is the basis of many physiological and pathological processes. Much is known about how inflammation is initiated, develops and evolves over the short term. But less is known about the causes and consequences of chronic, long-term inflammation that underlies many human diseases. Recent studies have expanded our understanding of the dialogue between inflammatory responses and physiological and pathological responses.


Potential Benefits of Theracurmin®

Highlights from some of the key studies follow and clearly show Theracurmin® has the potential to provide substantial benefits in many areas of human health.


Detoxification / Alcohol Metabolism

Acetaldehyde is an alcohol metabolite and known as a cause of hangover. Recently it has been reported that acetaldehyde is strongly related to various diseases. In the human clinical trial, seven healthy volunteers participated by drinking the same amount of alcohol (.05mL ethanol/kg weight). After 30 minutes, those who consumed a follow-up Theracurmin® beverage containing 30 mg of curcumin lowered their blood-acetaldehyde concentration significantly (25%) when compared to those who drank water alone (control). The study confirmed that Theracurmin® has a positive effect on the alcohol metabolism in healthy volunteers.

Change in Blood-Acetaldehyde Concentration figure

(Sasaki H., et al: Biol Pharm Bull.34(5):660-665, 2011)


Detoxification / Liver Function

In another study, Theracurmin® was orally administrated to healthy volunteers, including those with relatively high values for liver function markers such as gamma-glutamyl transpeptidase (γ-GTP), aspartate transaminase (AST), and alanine transaminase (ALT), at a dose of 180 mg of curcumin daily for 1 month. Significant decreases were observed in AST (−12%), ALT (−16%), and γ-GTP (−15%). Further, liver function was more markedly improved in subjects who had higher baseline values than in those with relatively normal ones.

Detoxification / Liver Function figure

(Otsuka Y, et al: The Journal of Japan Mibyou System Association 16(2):331-333, 2010)


Skin Care, Anti-aging

While acting as both an anti-oxidant and anti-inflammatory agent to protect skin from stress caused by UV rays, research has found that ingesting Theracurmin® can improve skin condition with increased moisture levels (at a dose of 60 mg of curcumin daily) and reduction of age spots (at a dose of 180 mg curcumin daily).

Skin Care, Anti-aging figure


Recovery from Muscle Fatigue

In crossover human clinical trials, Theracurmin® consumption at a dose of 150 mg of curcumin before and after exercise contributed to significantly faster recovery of muscle strength after extreme exercise. Additionally, creatine kinase (CK) activity in the blood — which is commonly used as a marker of muscle fiber damage — was attenuated in the Theracurmin® group.

Recovery from Muscle Fatigue figures

(Tanabe Y, et al: Eur J Appl Physiol 115:1949–1957, 2015)


Heart Failure

A double-blind clinical trial of 68 patients has shown that Theracurmin® can have positive effects on diastolic function in hypertensive patients with left ventricular hypertrophy. The patient group that ingested 60mg of curcumin a day for 24 weeks had a 12.7% reduction in LV stiffness (E/E’) when compared to the patient group that ingested a placebo. Left ventrical diastolic failure was less severe in the heart hypertrophy patients that consumed the Theracurmin doses. This may lead toward treatment and prevention of disastolic heart failure.

Heart Failure figure

(American Heart Association, Nov.12-16, 2011 / American College of Cardiology, March 26, 2012)


Arterial Stiffness

Multiple studies of double-blind clinical trials have been conducted to assess the effects of Theracurmin® on the arterial health of postmenopausal women. A combination of Theracurmin® ingestion (150mg of curcumin a day) and exercise training for 8 weeks was shown to significantly improve arterial compliance, vascular endothelial function and central arterial hemodynamics.


(Akazawa N., et al: Artery Research 7(1):67-72, 2013)
Flow-Mediated Dilation Change figure

(Akazawa N., et al: Nutr Res 32(10):795-799, 2012)


Central BP figure

(Sunagawa J., et al: Am J Hypertens, Vol 25-6, 651-656, 2012)



In this study, Theracurmin® was administered at a daily oral dose of 200mg or 400mg of curcumin along with Gemcitabine-based chemotherapy to 16 patients with refractory pancreatic or biliary tract cancer. The study documented their significantly improved quality of life scores by quantifying their experiences with fatigue, functional abilities, diarrhea, financial difficulties and appetite loss. 21% of the patients that ingested Theracurmin® during their treatment could survive more than one year.

(Kanai M., et al: Cancer Chemother Pharmacol. 30 March, 2013 Published online)


Knee Osteoarthritis

In a double-blinded, placebo-controlled, randomized, 8-week trial, 50 patients with medial knee osteoarthritis, aged 40 years or older, were divided into two groups of 25 people. The Theracurmin® group was given 180mg of curcumin a day and the results clearly indicated they experienced a significant reduction of knee pain when compared to the placebo group. In addition, the Theracurmin® group was able to reduce their dependence on NSAIDs to alleviate their pain.

(Nakagawa Y., et al: J Orthrop Sci. Vol. 19, Nov. 6, 2014)


Exercise-induced Oxidative Stress

In a doubled-blinded, placebo-controlled, counterbalanced crossover trial, Theracurmin® supplementation at a dose of 90mg of cur cumin two hours before exercise or two hours before and immediately after exercise significantly increased the serum concentration of biological antioxidant potential (BAP) and reduced glutathione (GSH).

excerciseimgfal(Takahashi et al. Int J Sports Med. 34: 1-7, 2013)


COPD (Chronic Obstructive Pulmonary Disease)



Mild cognitive impairment






Ongoing Clinical Trials

Research Area Institute/University
Heart failure / diastolic dysfunction: dose
escalation trial
Kyoto Medical Center
Colon cancer prevention Tokushima Univ.
Pelizaeus‐Merzbacher disease (PMD) NCNP National Institute of Neuroscience