Theracurmin® Literature and Published Articles



[TC028]  Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR.
The Effects of Curcumin on Brain-Derived Neurotrophic Factor and Cognition in Schizophrenia: A Randomized Controlled Study
Schizophr Res. 2018 May 195 572–573

[TC027]  Nishikawa S, Kamiya M, Aoyama H, Nomura M, Hyodo T, Ozeki A, Lee H, Takahashi T, Imaizumi A, Tsuda T.
Highly Dispersible and Bioavailable Curcumin but not Native Curcumin Induces Brown-Like Adipocyte Formation in Mice
Mol. Nutr. Food Res. 2018 Jan 62 (5) 1700731

[TC026]  Shin YA, Suk MH, Jang HS, Choi HJ.
Short-Term Effects of Theracurmin Dose and Exercise Type on Pain, Walking Ability, and Muscle Function in Patients with Knee Osteoarthritis
J Exerc Rehabil. 2017 Dec 13(6):684-692

[TC025]  Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR.
Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
2017 The American Journal of Geriatric Psychiatry, published by Elsevier

[TC024] Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR, Sedighiyan M, Djalali M, Mohammadzadeh Honarvar N, Djalali M.
The Synergistic Effects of ω-3 Fatty Acids and Nano-Curcumin Supplementation on Tumor Necrosis Factor (TNF)-α Gene Expression and Serum Level in Migraine Patients.
Immunogenetics. 2017 Jun 69(6):371-378

[TC023] Ohno M, Nishida A, Sugitani Y, Nishino K, Inatomi O, Sugimoto M, Kawahara M, Andoh A.
Nanoparticle Curcumin Ameliorates Experimental Colitis via Modulation of Gut Microbiota and Induction of Regulatory T Cells.
PLoS One. 2017 Oct 6;12(10):e0185999.

[TC022] Yamaguchi T, Yoneyama M, Onaka Y, Imaizumi A, Ogita K.
Preventive Effect of Curcumin and Its Highly Bioavailable Preparation on Hearing Loss Induced by Single or Repeated Exposure to Noise: A Comparative and Mechanistic Study.
J Pharmacol Sci. 2017 Aug;134(4):225-233.

[TC021]  Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS.
Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest.
2016 Oncol Rep. 35(3): 1463-1472

[TC020]  Bugyei-Twum A, Abadeh A, Thai K, Zhang Y, Mitchell M, Kabir G, Connelly KA.
Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction.
2016 Sci Rep. 6: 39551

[TC019]  Kato M, Nishikawa S, Ikehata A, Dochi K, Tani T, Takahashi T, Imaizumi A, Tsuda T.
Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion.
2016 Mol Nutr Food Res. 61(3): 471

[TC018]  Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T.
Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.
2016 Int J Chron Obstruct Pulmon Dis. 2016(11): 2029–2034

[TC017]  Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K.
Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.
2015 Eur J Appl Physiol. 115: 1949–1957

[TC016]  Sunagawa Y, Hirano S, Katanasaka Y, Niyazaki Y, Funamoto M, Okamura N, Hojo Y, Suzuki H, Doi O, Yokoji T, Morimoto E, Takahashi T, Ozawa H, Imaizumi A, Ueno M, Kakeya H, Shimatsu A, Wada H, Hasegawa K, Morimoto T.
Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency –A Double-Blind, 3-Way Crossover Study
2015 J Nutr Sci Vitaminol. 61. 37-44

[TC015]  Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihara J, Nakamura T.
Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study
2014 J Orthop Sci. 933-939

 [TC014]  Takahashi M, Suzuki K, Kim HK, Otsuka Y, Imaizumi A, Miyashita M, Sakamoto S.
Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans.
2013. Int J Sports Med. 35:469-475

[TC013]  Nazari QA, Kume T, Takada-Takatori Y, Imaizumi A, Hashimoto T, Izumi Y, Akaike A.
Potential Protective Effect of Highly Bioavailable Curcumin on Oxidative stress Model induced by microinjection of Sodium Nitroprusside in Mice Brain.
2014 Food Funct. 5(5):984-9

[TC012]  Kawanishi N, Kato K, Takahashi M, Mizokami T, Otsuka Y, Imaizumi A, Shiva D, Yano H, Suzuki K.
Curcumin attenuates oxidative stress following downhill running-induced muscle damage.
2013 Biochem Biophys Res Commun.;441(3):573-8

[TC011]  Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada Y, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K.
Drinkable Preparation of Theracurmin Exhibits High Absorption Efficiency—A Single-Dose, Double-Blind, 4-Way Crossover Study.
2013. Biol. Pharm. Bull. 36(11) 1708–1714.

[TC010]  Yamauchi Y, Izumi Y, Yamamoto J, Nomori H.
Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability in Lung Cancer Cells.
2013. Phytother Res. 28(5):728-35

[TC009]  Nazari QA, Kume T, Izuo N, Takada-Takatori Y, Imaizumi A, Hashimoto T, Izumi Y, Akaike A.
Neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture.
2013. Biol Pharm Bull. 36(8):1356-62.

[TC008]  Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK.
Nano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune response.
2013. Front Oncol. 29;3:137

[TC007]  Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.
Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women.
2013. Artery Research 7(1): 67-72

[TC006]  Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S,Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.
A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients.
2013. Cancer Chemother Pharmacol. 71(6): 1521-1530.

[TC005]  Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.
Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
2012. Nutr Res. 32(10):795-759.

[TC004]  Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S.
Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study.
2012. Am J Hypertens. 25(6):651-656

[TC003]  Sunagawa Y, Wada H, Suzuki H, Sasaki H, Imaizumi A, Fukuda H, Hashimoto T, Katanasaka Y, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K, Morimoto T.
A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.
2012. Biol Pharm Bull. 35(2):139-144.

[TC002]  Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T.
Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.
2012. Cancer Chemother Pharmacol. 69(1):65-70.

[TC001]  Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T.
Innovative preparation of curcumin for improved oral bioavailability.
2011. Biol Pharm Bull. 34(5):660-665.



[TCR003]  Imaizumi A.
Highly bioavailable curcumin (Theracurmin): its development and clinical application.
2015, PharmaNutrition available online 11 September 2015

[TCR002]  Kanai M.
Therapeutic applications of curcumin for patients with pancreatic cancer.
2014. World J Gastroenterol. 2014 Jul 28;20(28): 9384-9391.

[TCR001]  Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S.
Clinical Application of “Curcumin”, a Multi-Functional Substance.
2012. Anti-Aging Medicine 9(1): 43-51