Theracurmin® Literature and Published Articles


Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T.
Innovative preparation of curcumin for improved oral bioavailability.
2011. Biol Pharm Bull. 34(5):660-665.

Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T.
Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.
2012. Cancer Chemother Pharmacol. 69(1):65-70.

Sunagawa Y, Wada H, Suzuki H, Sasaki H, Imaizumi A, Fukuda H, Hashimoto T, Katanasaka Y, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K, Morimoto T.
A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.
2012. Biol Pharm Bull. 35(2):139-144.

Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S.
Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study.
2012. Am J Hypertens. 25(6):651-656

Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.
Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
2012. Nutr Res. 32(10):795-759.

Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S,Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.
A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients.
2013. Cancer Chemother Pharmacol. 71(6): 1521-1530.

Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S.
Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women.
2013. Artery Research 7(1): 67-72

Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK.
Nano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune response.
2013. Front Oncol. 29;3:137

Nazari QA, Kume T, Izuo N, Takada-Takatori Y, Imaizumi A, Hashimoto T, Izumi Y, Akaike A.
Neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture.
2013. Biol Pharm Bull. 36(8):1356-62.

Yamauchi Y, Izumi Y, Yamamoto J, Nomori H. Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability in Lung Cancer Cells.
2013. Phytother Res. 28(5):728-35

Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada Y, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K.
Drinkable Preparation of Theracurmin Exhibits High Absorption Efficiency—A Single-Dose, Double-Blind, 4-Way Crossover Study.
2013. Biol. Pharm. Bull. 36(11) 1708–1714.

Kawanishi N, Kato K, Takahashi M, Mizokami T, Otsuka Y, Imaizumi A, Shiva D, Yano H, Suzuki K.
Curcumin attenuates oxidative stress following downhill running-induced muscle damage.
2013 Biochem Biophys Res Commun.;441(3):573-8

Nazari QA, Kume T, Takada-Takatori Y, Imaizumi A, Hashimoto T, Izumi Y, Akaike A.
Potential Protective Effect of Highly Bioavailable Curcumin on Oxidative stress Model induced by microinjection of Sodium Nitroprusside in Mice Brain.
2014 Food Funct. 5(5):984-9

Takahashi M, Suzuki K, Kim HK, Otsuka Y, Imaizumi A, Miyashita M, Sakamoto S.
Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans.
2013. Int J Sports Med. 35:469-475

Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihara J, Nakamura T
Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study
2014 J Orthop Sci. 933-939

Sunagawa Y, Hirano S, Katanasaka Y, Niyazaki Y, Funamoto M, Okamura N, Hojo Y, Suzuki H, Doi O, Yokoji T, Morimoto E, Takahashi T, Ozawa H, Imaizumi A, Ueno M, Kakeya H, Shimatsu A, Wada H, Hasegawa K, Morimoto T
Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency –A Double-Blind, 3-Way Crossover Study
2015 J Nutr Sci Vitaminol. 61. 37-44

Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K
Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin.
2015 Eur J Appl Physiol. 115: 1949–1957

Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T
Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.
2016 Int J Chron Obstruct Pulmon Dis. 2016(11): 2029–2034

Kato M, Nishikawa S, Ikehata A, Dochi K, Tani T, Takahashi T, Imaizumi A, Tsuda T
Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion.
2016 Mol Nutr Food Res. 61(3): 471

Bugyei-Twum A, Abadeh A, Thai K, Zhang Y, Mitchell M, Kabir G, Connelly KA
Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction.
2016 Sci Rep. 6: 39551

Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS
Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest.
2016 Oncol Rep. 35(3): 1463-1472



Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S.
Clinical Application of “Curcumin”, a Multi-Functional Substance.
2012. Anti-Aging Medicine 9(1): 43-51

Kanai M.
Therapeutic applications of curcumin for patients with pancreatic cancer.
2014. World J Gastroenterol. 2014 Jul 28;20(28): 9384-9391.

Imaizumi A.
Highly bioavailable curcumin (Theracurmin): its development and clinical application.
2015, PharmaNutrition available online 11 September 2015