EMIQ® Literature & Published Articles

ORIGINAL PAPERS

Tamano D, Hatahara Y, Sano M, Hagiwara A, Nakamura M, Washino T, Imaida K
13-Week oral toxicity and 4-week recovery study of enzymatically modified isoquercitrin in F344/DuCrj rats.
2001, Jpn. J. Food Chem., 8(3) 161-167
http://ci.nii.ac.jp/els/110007367233.pdf?id=ART0009227016&type=pdf&lang=jp&host=cinii&order_no=&ppv_type=0&lang_sw=&no=1396493577&cp=

Salim EI, Kaneko M, Wanibuchi H, Morimura K, Fukushima S.
Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats.
2004, Food Chem Toxicol.;42(12):1949-1969
http://www.ncbi.nlm.nih.gov/pubmed/15500932

Tamura S, Tsujii K, Moriwaki M, Murakami N
Metabolic behavior of enzymatically modified isoquercitrin by α-amylase and gastric juices
2005, Jpn. J. Food Chem., 12(3) 152-155
http://ci.nii.ac.jp/els/110007367326.pdf?id=ART0009227246&type=pdf&lang=jp&host=cinii&order_no=&ppv_type=0&lang_sw=&no=1396500106&cp=

Emura K, Yokomizo A, Toyoshi T. Moriwaki M.
Effect of enzymatically modified isoquercitrin in spontaneously hypertensive rats
2007. J Nutr Sci Vitaminol 53, 68–74.
http://www.ncbi.nlm.nih.gov/pubmed/17484383

Yokohira M, Yamakawa K, Saoo K, Matsuda Y, Hosokawa K, Hashimoto N, Kuno T, Imaida K.
Antioxidant effects of flavonoids used as food additives (purple corn color, enzymatically modified isoquercitrin, and isoquercitrin) on liver carcinogenesis in a rat medium-term bioassay.
J Food Sci. 2008 Sep;73(7):C561-8
http://www.ncbi.nlm.nih.gov/pubmed/18803703

Yoshimura M, Maeda A, Takehara I, Abe K, Ohta H, Kiso Y, Fukuhara I, Sakane N
Body fat reducing effect and safety of the beverage containing polyphenols derived from Japanese pagoda tree (enzymatically modified isoquercitrin) in overweight and obese subjects
2008, Pharmacol Ther., 36(10) 919-930
http://www.lifescience.co.jp/yk/yk08/oct/ab4.html
* Japanese

Ishikura Y, Hujii W, Sakakibara Y, Kitogo T, Katagiri Y, Oki M
Safety evaluation of excessive intake of the drink containing Japanese pagoda tree polyphenol (enzymatically modified isoquercitrin) in healthy adults include obesity persons
2008, Jpn Pharmacol Ther., 36(10) 931-939
http://www.lifescience.co.jp/yk/yk08/oct/ab5.html
* Japanese

Tateishi N, Egawa K, Kanzaki N, Kitagawa Y, Shibata H, Kiso Y, Emonoto S, Fukuda D, Nagai R, Sata M
Effects of quercetin glucosides on diet-induced obesity in mice -The lipolytic activity of quercetin.
2009, Jpn Pharmacol Ther., 37(2) 123-131
http://www.lifescience.co.jp/yk/yk09/feb/ab4.html
* Japanese

Matsuno H, Nakamura H, Katayama K, Hayashi S, Kano S, Yudoh K, Kiso Y.
Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis.
2009, Biosci Biotechnol Biochem.;73(2):288-292
http://www.ncbi.nlm.nih.gov/pubmed/19202302

Motoyama K, Koyama H, Moriwaki M, Emura K, Okuyama S, Sato E, Inoue M, Shioi A, Nishizawa Y.
Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoEdeficient mice.
2009. Nutrition, 25, 421-427.
http://www.ncbi.nlm.nih.gov/pubmed/19026522

Kawai M, Hirano T, Arimitsu J, Higa S, Kuwahara Y, Hagihara K, Shima Y, Narazaki M, Ogata A, Koyanagi M, Kai T, Shimizu R, Moriwaki M, Suzuki Y, Ogino S, Kawase I, Tanaka T.
Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: arandomized double-blind placebo-controlled trial.
2009. Int Arch Allergy Immunol. 149(4):359-368
http://www.ncbi.nlm.nih.gov/pubmed/19295240

Hirano T, Kawai M, Arimitsu J, Ogawa M, Kuwahara Y, Hagihara K, Shima Y, Narazaki M, Ogata A, Koyanagi M, Kai T, Shimizu R, Moriwaki M, Suzuki Y, Ogino S, Kawase I, Tanaka T.
Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis.
2009. Allergol Int. 58(3):373-82.
http://www.ncbi.nlm.nih.gov/pubmed/19454839

Makino T, Shimizu R, Kanemaru M, Suzuki Y, Moriwaki M, Mizukami H.
Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats.
2009, Biol Pharm Bull..;32(12):2034-2040
http://www.ncbi.nlm.nih.gov/pubmed/19952424

Shimada Y, Dewa Y, Ichimura R, Suzuki T, Mizukami S, Hayashi SM, Shibutani M, Mitsumori K.
Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone.
2010. Toxicology. 9;268(3):213-218
http://www.ncbi.nlm.nih.gov/pubmed/20045035

Nishimura J, Saegusa Y, Dewa Y, Jin M, Kawai M, Kemmochi S, Harada T, Hayashi SM, Shibutani M, Mitsumori K
Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stressmediated hepatocellular tumor promotion of oxfendazole in rats.
2010, Arch Toxicol.;84(2):143-153
http://www.ncbi.nlm.nih.gov/pubmed/20033131

Murota K, Matsuda N, Kashino Y, Fujikura Y, Nakamura T, Kato Y, Shimizu R, Okuyama S, Tanaka H, Koda T, Sekido K, Terao J.
Alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans.
2010, Arch Biochem Biophys.;501(1):91-97
http://www.ncbi.nlm.nih.gov/pubmed/20638359

Kuwata K, Shibutani M, Hayashi H, Shimamoto K, Hayashi SM, Suzuki K, Mitsumori K.
Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats.
2011, Toxicology.;283(1):8-17
http://www.ncbi.nlm.nih.gov/pubmed/21295105

Morita R, Shimamoto K, Ishii Y, Kuwata K, Ogawa B, Imaoka M, Hayashi SM, Suzuki K, Shibutani M, Mitsumori K.
Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.
2011, Arch Toxicol.;85(11):1475-1484
http://www.ncbi.nlm.nih.gov/pubmed/21445586

Kanzaki N, Saito K, Maeda A, Kitagawa Y, Kiso Y, Watanabe K, Tomonaga A, Nagaoka I, Yamaguchi H.
Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study.
2012 Mar 15 J Sci Food Agric.;92(4):862-869
http://www.ncbi.nlm.nih.gov/pubmed/21969261

Egawa K, Yoshimura M, Kanzki N, Nakamura J, Kitagawa Y, Shibata H, Fukuhara I
Body fat reducing effect and safety evaluation of long-term consumption of green tea containing quercetin glucoside in obese subjects
2012, Jpn Pharmacol Ther., 40(6) 495-503
http://www.lifescience.co.jp/yk/yk12/jun/ab4.html
* Japanese

Ishikura Y, Fujii W, Sakakibara W, SakanoK, Hayashi M, Ebihara S
Safety evaluation of excessive intake of the green tea beverage containing quercetin glycoside (enzymatically modified isoquercitrin) in healthy adults include obesity persons
2012, Jpn Pharmacol Ther., 40(6) 505-512
http://www.lifescience.co.jp/yk/yk12/jun/ab5.html
* Japanese

Yoshimura M, Maeda A, Nakamura J, Kitagawa Y, Shibata H, Fukuhara I
Body fat reducing effect of continuous consumption of the beverage containing quercetin glucosides (enzymatically modified isoquercitrin) in obese subjects
2012, Jpn Pharmacol Ther., 40(10) 901-914
http://www.lifescience.co.jp/yk/yk12/oct/ab8.html
* Japanese

Fujii Y, Kimura M, Ishii Y, Yamamoto R, Morita R, Hayashi SM, Suzuki K, Shibutani M.
Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats.
Toxicology. 2013 Mar 8;305:30-40
http://www.ncbi.nlm.nih.gov/pubmed/23318833

Makino T, Kanemaru M, Okuyama S, Shimizu R, Tanaka H, Mizukami H.
Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice.
2013, J Nat Med..;67(4):881-6
http://www.ncbi.nlm.nih.gov/pubmed/23494818

Hara S, Morita R, Ogawa T, Segawa R, Takimoto N, Suzuki K, Hamadate N, Hayashi SM, Odachi A, Ogiwara I, Shibusawa S, Yoshida T, Shibutani M.
Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model.
Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34
http://www.ncbi.nlm.nih.gov/pubmed/24680176

Saito K, Tanaka T, Obata H, Nakamura J, Fukui N, Tonozuka N.
Body Fat Reducing Effect and Safety Evaluation of Long-term Consumption of Tea Containing Quercetin Glucosides in Obese Subjects
2015, Jpn Pharmacol Ther., 43(2) 181-194
http://www.lifescience.co.jp/yk/yk15/feb/ab4.html
* Japanese

Yasutake Y, Hori H, Kitagawa Y, Sugimura H.
Safety Evaluation of Excessive Intake of Tea Containing Quercetin Glucosides in Healthy Adults Including Obese Subjects -A Randomized, Double-blind, Placebo-controlled, Parallel-group Study
2015, Jpn Pharmacol Ther., 43(3)389-396
http://www.lifescience.co.jp/yk/yk08/oct/ab5.html
* Japanese